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Opus Genetics presents positive Phase 1/2 data for OPGx-BEST1 and OPGx-LCA5, with LCA5 Phase 3 dosing expected in Q4 2026

IRDOpus Genetics, Inc.

Opus Genetics presented interim clinical data from its gene therapy programs at the Retina in Rio 2026 conference. For OPGx-BEST1, Cohort 1 results showed improved retinal sensitivity in three of four evaluable participants (75%), with structural improvements linked to functional gains. For OPGx-LCA5, sustained improvements in visual acuity and light sensitivity were observed through 24 months in adults and six months in pediatric participants. The Phase 3 trial for OPGx-LCA5 is fully enrolled, with dosing initiation expected in the fourth quarter of 2026. Opus Genetics operates as a clinical-stage biopharmaceutical company developing gene therapies to restore vision and prevent blindness in patients with inherited retinal diseases.

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