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Adds Clear Street as sales agent to existing equity distribution agreement

XXII22nd Century Group, Inc.

The company entered into Amendment No. 2 to its Sales Agreement with Needham & Company LLC, adding Clear Street LLC as an additional sales agent for the ongoing at-the-market equity offering program established in November 2025. This administrative change expands the distribution network but does not alter the terms of the existing agreement or raise new capital immediately. The company operates in the tobacco alternatives and cannabis sectors.

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