Spyre Therapeutics, Inc. (SYRE)
Pharmaceutical Preparations
Latest Price
$90.95
TTM P/E
--
Normalized P/E
--
Div Yield
--
Book Value
6.43
P/B Ratio
14.14
Valuation metrics
adjust assumptions →EPS: $13.76
Book value / share: $9.15
Formula: √(22.5 × EPS × BVPS)
Graham Number
$53.22
41% downside
EPS: $13.76
Target P/E: 15×
Formula: EPS × P/E
P/E Fair Value
$206.40
+127% upside
Institutional Ownership
100.0% held by institutions| Institution | Shares | Value | Ownership % | Change | Filing Date |
|---|---|---|---|---|---|
| FMR LLC | 13.03M | $1.16B | 14.79% | +1.25M | 2026-06-30 |
| BlackRock, Inc. | 6.51M | $577.0M | 7.39% | +985.4K | 2026-06-30 |
| PERCEPTIVE ADVISORS LLC | 4.32M | $383.0M | 4.90% | +536.3K | 2026-06-30 |
| RTW INVESTMENTS, LP | 4.25M | $377.0M | 4.83% | +80.0K | 2026-06-30 |
| Paradigm Biocapital Advisors LP | 3.84M | $340.0M | 4.36% | +1.88M | 2026-06-30 |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.45M | $306.0M | 3.92% | +391.3K | 2026-06-30 |
| STATE STREET CORP | 3.06M | $271.0M | 3.47% | +450.4K | 2026-06-30 |
| Venrock Adviser, LLC | 2.99M | $265.0M | 3.39% | -700.0K | 2026-06-30 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.96M | $262.0M | 3.36% | +1.36M | 2026-06-30 |
| Driehaus Capital Management LLC | 2.80M | $248.0M | 3.18% | +8.4K | 2026-06-30 |